article relates to the synthesis of tetrahydrobenzo[1,2-b:4,5-b]difuran which is an important organic intermediate. Beginning with hydroquinone,through alkylation, bromination and cyclization with Grignard reaction, the heterocyclic nucleus of tetrahydro-benzo[1,2-b;4,5-b]difuran is builded. Then the tetrahydrobenzo- [1,2-b:4,5-b]difuran reacts with D-or L-alanine, followed by ketone reduction, to produce an important organic intermediate. With this intermediate, then a series of derivatives can be prepared. These derivatives often have highe affinity acting on 5-HT Receptor, so have pharmaceutically- researched value. In the present experiments, tetrahydrobenzo-[1,2-b:4.5b]difuran is prepared in total yield of 40% and the tetrahydrobenzo-[1,2-b:45b]difuran reacts with alanine to produce derivatives in a yield of 66%.