5-氨基-3-巯基-1, 2, 4-三唑的合成

论文编号:ZY067    论文字数:9592,页数:22

摘 要：5-氨基-3-巯基-1，2，4-三唑（简称AMZ）是重要的有机合成中间体，在农药、医药和成像材料等领域有广泛的用途。本文在查阅大量文献的基础上，通过比较各种方法的优缺点提出了合成5-氨基－3－巯基－1，2，4－三唑（简称AMZ）最理想的路线：以氨基胍碳酸氢盐与硫氰酸铵为原料合成目标产物。并通过对反应物物质的量之比、反应溶剂量以及反应的温度的实验探索，得出合成目标产物的最佳工艺条件是：氨基胍盐与硫氰酸铵的物质的量之比为1：1.2；氨基胍盐与氢氧化钠物质的量之比为1:1.3；加盐酸温度为98℃；加氢氧化钠温度110℃；在上述优化条件下，AMZ的产率为83.90%。

关键词：农药；除草剂；合成；5-氨基-3-巯基-1,2,4-三唑;

Abstact: 5-amino-3-mercapto-1,2,4-triazole （AMZ） is an important intermediate in organic synthesis. It has widespread usage in the fields of pesticide, medicine, imaging materials and so on. Based on the consultation of a large number of literature and the comparison of the advantages and disadvantages of various methods about the synthesis of 5-amino-3-mercapto-1,2,4-triazole （AMZ）, the best route is: take aminoguanidine bicarbonate and ammonium thiocyanate as raw materials to synthesize the product. And based on the experimental explorations of the amount of adducts, reaction solvent volume, and reaction temperature, the optimum conditions of this route are: the ratio of the amount between aminoguanidine salt and ammonium thiocyanate is 1:1.2; the ratio of the amount between aminoguanidine salt and sodium hydroxide is 1:1.3; the temperature of hydrochloride is 98 ° C; the temperature of sodium hydroxide is 110 ° C; In optimum conditions, the yield of AMZ is 83.90%.

Key words:  pesticide; herbicide; synthesis; AMZ;

目  录

中文摘要 I
英文摘要 II
目录 III
1 绪论 1
      1.1 除草剂的研究现状及其分类 1
2 实验部分 9
2.1 实验试剂 9
 2.2 实验仪器 9
 2.3 实验装置 10
 2.4 实验步骤 10
3 结果与讨论 ..12
 3.1 以氨基胍碳酸氢盐与硫氰酸铵为原料合成AMZ 12
 3.2 以氨基胍（盐）与二硫化碳为原料合成AMZ 13
 3.3 以肼与硫氰酸铵为原料合成AMZ 14
 3.4 合成AMZ的最佳工艺路线 14
4 总结与展望 17
致谢 18
参考文献 19

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